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Olema Oncology to evaluate OP-1250, palbociclib combo in advanced breast cancer

Olema Oncology to evaluate OP-1250, palbociclib combo in advanced breast cancer

Olema Oncology has entered into a clinical trial agreement with Pfizer to evaluate its small molecule OP-1250 in combination with the latter’s palbociclib (IBRANCE) in advanced breast cancer. OP-1250 is an estrogen receptor (ER) antagonist (CERAN) and a selective ER degrader (SERD). Its combination with the Pfizer breast cancer drug will be assessed in the […]

BNT162b2 Covid-19 vaccine candidate more than 90% effective in phase 3 trial, say Pfizer and BioNTech

Pfizer and BioNTech announced that the BNT162b2 mRNA-based vaccine candidate has been shown to be more than 90% effective in the prevention of Covid-19 in participants of a phase 3 trial who were not previously exposed to the SARS-CoV-2 infection. The data is based on the first interim efficacy analysis from the phase 3 clinical […]

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Pfizer’s tofacitinib succeeds in phase 3 ankylosing spondylitis trial

Pfizer said that a phase 3 clinical trial of XELJANZ (tofacitinib) in adults with active ankylosing spondylitis (AS) has met its primary endpoint. The late-stage study’s primary endpoint is assessment in SpondyloArthritis International Society (ASAS) 20 response, compared to placebo at week 16. This was after the percentage of patients achieving an ASAS20 response was […]

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Covid-19 phase 3 trial of lenzilumab : Humanigen announces positive interim results

Humanigen said that lenzilumab has delivered a clinically meaningful impact on the recovery of patients hospitalized with Covid-19, as per the interim data of a phase 3 trial. According to the US biopharma company, the interim analysis for sizing and powering, an estimated 37% more recoveries were seen in the lenzilumab arm of the randomized, […]

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Seres Therapeutics begins phase 1b trial of SER-301 in ulcerative colitis

Seres Therapeutics has dosed the first patient in a phase 1b clinical trial, which is assessing SER-301 for the treatment of active mild-to-moderate ulcerative colitis (UC). According to the US-based biotech company, SER-301 is an oral fermented microbiome therapeutic designed for dampening the unusual gastrointestinal inflammation central to ulcerative colitis and promote clinical remission in […]

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AstraZeneca resumes AZD1222 Covid-19 vaccine trials after brief pause

AstraZeneca said that clinical trials for the AZD1222 Covid-19 vaccine candidate, have resumed in various parts of the world after regulators across the US, UK, Brazil, Japan, and South Africa confirmed that it was safe to continue them. The US Food and Drug Administration (FDA) has authorized the restart of AZD1222 clinical trials in the […]

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VelosBio begins phase 2 trial of VLS-101 in solid tumors

VelosBio, a San Diego-based biopharma company, said that it has dosed the first patient in a phase 2 clinical trial of its investigational antibody-drug conjugate (ADC) VLS-101 in patients having solid tumors. VLS-101, which is the company’s lead product candidate, targets a cell-surface protein called ROR1. Expressed during embryofetal development, ROR1 is however not seen […]

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AstraZeneca to advance AZD7442 into phase 3 Covid-19 trials

AstraZeneca said that AZD7442, which is being developed for the prevention and treatment of Covid-19, will move into two phase 3 clinical trials. AZD7442 is a combination of a couple of monoclonal antibodies (mAbs) extracted from convalescent patients with SARS-CoV-2 infection. It will be assessed in more than 6,000 participants at sites in and outside […]

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IBRANCE fails to meet primary endpoint in early breast cancer trial

Pfizer said that the phase 3 PENELOPE-B clinical trial of IBRANCE (palbociclib) in early breast cancer failed to meet its primary endpoint. The collaborative late-stage trial is being held by the US pharma giant with the German Breast Group (GBG) sponsoring it. The primary endpoint of the PENELOPE-B clinical trial is improved invasive disease-free survival […]

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VirTrial to help BetterLife Pharma in launching COVID-19 clinical trials

VirTrial, a US bioscience technology company, has been selected by Canadian biotech company BetterLife Pharma as its telehealth platform provider of choice for launching COVID-19 clinical trials. The partnership will help BetterLife Pharma to carry out remote patient monitoring for its upcoming COVID-19 clinical trials in Australia for evaluating the efficacy of its interferon alpha 2b formulation […]

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