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MERU clinical trial : AbbVie ends Rova-T program in lung cancer

Following undesired results from the phase 3 MERU clinical trial, US biopharma company AbbVie has terminated the research and development program of Rovalpituzumab Tesirine (Rova-T), an investigational lung cancer drug.

The MERU clinical trial is being closed over futility with the phase 3 study, which was assessing Rova-T as a first-line maintenance therapy for advanced small-cell lung cancer (SCLC) failed to show any survival benefit. This was at a pre-planned interim analysis in the Rova-T patient arm compared to the placebo arm.

AbbVie revealed that an independent data monitoring committee (IDMC) recommended terminating the MERU clinical trial because of the lack of survival benefit with Rova-T treatment. The MERU trial results will be presented at a medical meeting in the future and/or published in a peer-reviewed medical journal, said the US biopharma company.

MERU clinical trial Rova-T Abbvie

AbbVie ends Rova-T program in lung cancer after failed MERU clinical trial. Photo courtesy of AbbVie Inc.

The overall safety profile of Rova-T was in general in line with that observed in previous clinical trials, said AbbVie.

The US biopharma company will move ahead prioritizing other development programs from its oncology pipeline.

Commenting on the MERU clinical trial of Rova-T in advanced small-cell lung cancer, Margaret Foley –  AbbVie vice president, global head of solid tumor development, said: “Small-cell lung cancer continues to be one of the most difficult-to-treat cancers where there is a significant need for transformative therapies. We are disappointed with this outcome for the patients who suffer from this disease.

“We remain committed to researching and developing other therapies with the potential to transform care for patients with small-cell lung cancer and other malignancies.”

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One Response to MERU clinical trial : AbbVie ends Rova-T program in lung cancer

  1. I am a 51 year old female that just found out I have Parkinson’s, but I have been having signs of it for years, tremors, depression, body weakness. ECT. I honestly don’t think my doctor was reading the signs because of my gender and age. A few years ago I had my shoulder lock up on me and I was sent to a P.T since x-rays didn’t show any physical damage. My shaking was getting worse and I began falling. Only when my speech became so bad that it brought concern to my dentist was Parkinson’s even considered. He phoned my doctor with his concerns about my shaking and balance problems. By this time I was forgoing shots in the back of my neck for back and neck pain to which once again I was sent to a P.T (although x-rays showed no damage) I was told I had a few spurs which were most likely causing the pain. Here I was feeling like my whole body was falling apart and doctor could not find anything wrong, maybe in was all in my head? My doctor even seemed annoyed with me and things just kept progressing and I just kept it to myself, why bother going through testing and them finding nothing? Well, it was after my second P.T called my doctor about the weakness in my legs and arms, by this time I have developed a gait in my walk and I fell more frequently. Only then did my doctor send me to a specialist and it was found that I had Parkinson’s, and that I have had it for awhile. I think because I was a woman that my signs and symptoms weren’t taken seriously and therefor left untreated for so long,I was taking pramipexole dihydrochloride three times daily, I Was on carbidopa levodopa but only lasted 90 minutes then wore off.I found that none of the current medications worked effective for me.I got tired of using those medication so I decided to apply natural herbs formula that was prescribed to me by my second P.T, i purchase the herbal formula from totalcureherbsfoundation. com, There has been huge progression ever since I start the treatment plan which will last for 15 weeks usage.all the symptoms and sign has begin to disappear .

    Carlos Benita
    September 13, 2019 at 7:28 am
    Reply

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